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Andriol is
a unique oral testosterone product, developed by the international drug
firm Organon. One of the more recently developed anabolic steroids,
Andriol first became available in the early 1980's. Andriol contains 40 mg
of testosterone undecanoate, based in oil (oleic acid) and sealed inside a
capsule. Subtracting the ester weight, this equates to a dosage of
approximately 25 mg of raw testosterone per cap. The design of Andriol is
quite different from that of most oral steroids. Drugs administered orally
generally enter the blood stream through the liver. When a steroid
compound is given this way without some form of structural protection, it
will be quickly broken down during the "first pass". This process leaves
very little steroid intact, basically deactivating the drug. Adding a
methyl group (c-17 AA) to the structure is one way to protect it from this
process, however stress is also placed on the liver as a result. In some
instances this stress can lead to actual damage to liver tissues, so the
designers of this steroid sought another way to protect the testosterone
molecule. With Andriol, this was accomplished by making a form of
testosterone that would be absorbed through the lymphatic system. This is
due to its high fat solubility brought about by the ester, and its
suspension in oil. Having the compound absorbed this way was thought to be
very advantageous, as it allows the steroid to bypass the destructive
first-pass through liver. This should permit the compound to enter the
blood stream intact, without the need for a harsh chemical alteration. The
ester breaks off once it is in circulation of course, yielding free
active. In design Andriol appears to be that of a completely liver safe
and orally active form of testosterone.
On paper
Andriol seems like an ideal oral testosterone product.
Clean, safe and worlds apart from other oral testosterone derivatives like
the crude methyltestosterone. But as we always hear in life, if it looks
to good to be true, it probably is. And there are definitely some issues
with Andriol. The first problem is that bioavailability, although clearly
worlds apart from trying to take straight testosterone orally, is probably
not significant next to c17-alpha alkylated orals. Athletes typically find
that in doses of less than 240 mg per day (6 capsules) effects are
generally not seen at all. 240 mg of testosterone ester daily, the primary
male androgen, and only a meager effect. When doses go higher, maybe 8-10
capsules (320-400 mg) , new muscle growth is slight to moderate at best,
but no incredible bulky gains are ever reported. Logic leads one to think
that only a little testosterone is making its way into circulation.
Testosterone is a powerful hormone no matter what the ester or form of
administration. If it were active in the blood stream, the results would
have to be pronounced. When one injects an oil based testosterone ester, a
dosage of 400 mg per week is more than sufficient. 400 mg Andriol per day
should be packing on an incredible amount of mass. Where does it all go?
Individual problems with
Andriol
absorption may play into
things here. Clearly there is little to be said except that this drug is
unpredictable in its ability to be absorbed and utilized by the body.
While one day you might be getting great absorption, perhaps the next day
you are getting very little. Studies with men were no better than with
women, where again Andriol was shown to be unpredictably absorbed and
utilized.
One might also pay interest to
the "mildness" of
Andriol as described by other
bodybuilding materials. Andriol is often spoken about as some type of
magic product, which to spite being a form of regular testosterone somehow
allows for only minimal estrogen conversion. You should know that the way
a drug is administered includes a number of factors that can slightly
alter its effect, the most predominant being the speed of release. This
effects the time it takes for a peak blood level to be reached, and likely
the length it takes to see results. The primary reason testosterone
suspension seems more powerful than
enanthate is because more drug is active on day one. At the same time
estrogen builds up faster and side effects become pronounced very quickly.
The ester is also part of the total weight, and 100 mg testosterone
contains a much larger quantity of testosterone molecules that
testosterone plus ester, another reason for varying effect. But these
changes do not amount to all that much. The structure of testosterone is
what allows it to break down into estrogen. The only way we can really
prevent an androgen from converting to estrogen is to change the base
molecule, not the ester. Once free in the blood stream we cannot prevent
testosterone from being aromatized without interfering with the aromatase
enzyme itself. The lack of results and side effects often reported with
Andriol must be going hand in hand with poor absorption.
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Buy Andriol :: |
