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Clenbuterol is a widely used bronchodilator in many parts of the world.
Clenbuterol is most often prepared in 20 mcg tablets, but it is also
available in syrup and injectable form. Clenbuterol belongs to a broad
group of drugs knows as sympathomimetics. Clenbuterol
affect
that sympathetic nervous system in a wide number of ways, largely mediated
by the distribution of adrenoceptors. There are actually nine different
types of these receptors in the body, which are classified as either alpha
or beta and further subcategorized by type number. Depending on the
specific affinities of these agents for the various receptors, they can
potentially be used in the treatment of conditions such as asthma,
hypertension, cardiovascular shock, arrhythmias, migraine headaches and
anaphylactic shock.
The drug Clenbuterol is
specifically a selective beta-2 sympathomimetic, primarily affecting only
one of the three subsets of beta-receptors. Of particular interest is the
fact that this drug has little beta-1 stimulating activity. Since beta-1
receptors are closely tied to the cardiac effects of these agents, this
allows Clenbuterol to reduce reversible airway obstruction (and effect of
beta-2 stimulation) with much less cardiovascular side effects compared to
non-selective beta agonists. Clinical studies with Clenbuterol show
Clenbuterol is extremely effective as a bronchodilator, with a low level
of user complaints and high patient compliance. Clenbuterol also exhibits
an extremely long half-life in the body, which is measured to be
approximately 34 hours long. This makes steady blood levels easy to
achieve, requiring only a single or twice daily dosing schedule at most.
This of course makes it much easier for the patient to use, and may tie in
to its high compliance rate. To spite that Clenbuterol is available in a
wide number of other countries however; this compound has never been
approved for use in the United States. The fact that there are a number of
similar, effective asthma medications already available in this country
may have something to do with this, as a prospective drug firm would
likely not find it a profitable enough product to warrant undergoing the
expense of the FDA approval process.
In animal studies
Clenbuterol is shown to exhibit anabolic activity, obviously an attractive
trait to the athlete. Clenbuterol is additionally a known thermogenic,
with beta-2 agonists like Clenbuterol shown to directly stimulate fat
cells and accelerate the breakdown of triglycerides to form free fatty
acids. Its efficacy in this area
makes Clenbuterol a very
attractive, and today almost mandatory, pre-contest drug. Those interested
in this drug are most often hoping it will impart a little of both
benefits, promoting the loss of body fat while imparting strength and
muscle mass increases. But possible anabolic activities in humans are very
questionable, and based only on animal data using much larger doses than
would be required for bronchodilation. With such reports there has been a
lot of debate lately as to whether or not Clenbuterol is really anabolic
at all. Some seem to swear by the fact that it builds muscle regardless,
firmly sticking by "clen" as a great off-season or adjunct anabolic. To
others such reports are confirmation that athletes have wasted valuable
time and money on drugs that do not work as they are intended to by the
user.
This debate continues today,
with many still using Clenbuterol as a potential anabolic. With this in
mind athletes will tailor their dosage and cycling of this product
individually depending on which of the two "possible" results are more
desired, and how much side effects are to be tolerated. The possible side
effects of Clenbuterol include those of other CNS stimulants, and include
such occurrences as shaky hands, insomnia, sweating, increased blood
pressure and nausea. These side effects will generally subside after a
week or so of use however, once the user becomes accustomed to the drug.
One would typically start a cycle by gradually increasing the dosage each
day until a desired range is established. This process will minimize the
unwanted side effects seen from the drug; which otherwise might be
dramatic if a large dose is administered from the onset. Men generally end
up in the range of 2-8 tablets per day, although some people do claim to
tolerate even higher dosages. Women get by on less, generally 2-4 tablets
daily. Very quickly, the drug will elevate the body temperature. The rise
is not usually dramatic, perhaps a half of a degree or so, sometimes a
little more. This elevation is due to your body burning excess energy
(largely from fat) and is usually not uncomfortable.
Now that it is working, the
number of consecutive days Clenbuterol can be used is believed to be
dependent on the goal of the individual. To be clear, the athletic
benefits of Clenbuterol will only last for a limited time and then
diminish, largely due to beta-receptor down
regulation. When using it
for fat loss, the primary effect of the drug, it seems to work well for
approximately 4-6 weeks. During this period, users will want to constantly
monitor their body temperature. We are assured Clenbuterol is working by
the temperature elevation. Once the temperature drops back to normal,
Clenbuterol is no longer exhibiting a thermogenic effect. At this point
increasing the dosage would not be very effective, and a break for at
least a few weeks should be taken before it is used again effectively. If
one is looking for strength gains, Clenbuterol appears to be effective for
a much shorter period of time, around 3-4 weeks. This may be due to an
absence of real anabolic effect, with the strength gain seen with
Clenbuterol possibly due only to the stimulant properties of the drug
(similar to the strength boost seen by ephedrine users). Again however,
this is still debated.
Many competitors also find the fat burning effect of Clenbuterol can be
further enhanced by additional substances. When combined with thyroid
hormones, specifically the powerful Cytomel, the
thermogenic effect can become extremely dramatic. This can be to a point
that the athlete could shred exceptional amounts of extra fat during
contest preparations, without a dramatic restriction in calories. Such a
mix can be further used during a steroid cycle, eliciting a much harder
look from the anabolics. These cutting agents can often greatly inhibit
extra fat storage during the cycle, even when using strong aromatizing
androgens. A Clenbuterol/thyroid mix is also common when using growth
hormone, further enhancing the thermogenic and anabolic effect of this
therapy.
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