The thyroid hormone, thyroxine
(T4) is a tyrosine-based hormone which is produced by the thyroid gland.
Synthetic versions of this hormone are used to make up for a lack of
naturally produced thyroxine and increase the rate of metabolism.
Artificially made thyroid hormone improves the symptoms of hypothyroidism
(underactive thyroid) and speeds the rate of metabolism in those who
suffer from the disease. Thyroid hormones may also be used to treat goiter
(enlarged thyroid gland) and certain types of thyroid cancer.
Thyroid hormone controls the
rate of metabolism. When the thyroid is under active, all body processes
slow down and symptoms such as weight gain, fatigue, and decreased body
temperature are experienced. Through supplementation of thyroid hormones,
basal metabolic rate will be increased.
Thyroid
hormones are essential to proper development of all cells in body. These
hormones allow for the body to become more sensitive to all other
hormones, in turn making them more effective. Thyroid hormones also
regulate macronutrient (protein, fat and carbohydrate) metabolism,
therefore increasing protein synthesis and ultimately energy. This allows
for the body to burn more calories and use them more sufficiently. For
this reason, thyroid hormones are commonly used as fat-loss drugs.
This medicine
does not typically cause side effects as long as proper dosages are
administered. However some drawbacks of Thyroid drug use are cardiac
stress and possible loss of lean body mass. Negative feedback in the
thyroid can decrease natural production of thyroid hormone, causing short
term decrease of metabolic rate after use is discontinued.
Many
studies have proven that while calories and carbohydrates are restricted,
levels of diodinase, the enzyme that activates thyroid hormone production,
decreased. The conversion of T4 into T3, the active form of thyroid
hormone, was became hindered. Users discovered
T3
(Cytomel) to be a better choice over T4 when using Thyroid drugs
during Cyclic Ketogenic Diets.
T4 must be used in much
higher doses to be as effective as T3. Subjects found they needed to use a
dosage of 300 mcg/day to achieve the same results as 25-100 mcg/day of
T3 (Cytomel).
Anecdotally, many bodybuilders feel that T4 is less harsh on muscle tissue
and they’re able to maintain more muscle when dieting down by using T4,
than compared with when they’ve used
T3 (Cytomel).
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